Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells

Fitoterapia. 2011 Apr;82(3):331-41. doi: 10.1016/j.fitote.2010.11.002. Epub 2010 Nov 9.

Abstract

We investigated the antitumour activity of Tithonia diversifolia (TD) on malignant glioblastoma cells. Our results suggested that tagitinin C was the main component in viability inhibition on malignant glioblastoma cells, and also accounted to be the most abundant component (>65%) in TD extract. Both TD extract and tagitinin C exhibited vigorous potential to produce in vitro viability inhibition, autophagic cell death and G2/M arrest. Furthermore, the activity of survivin, a critical resistant-factor in cancer therapy, could be downregulated significantly by TD extract and tagitinin C. These findings suggested that TD extract and tagitinin C were effective for treating malignant glioblastoma.

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Asteraceae / chemistry*
  • Autophagy / drug effects
  • Cell Cycle / drug effects*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Down-Regulation
  • Glioblastoma / drug therapy*
  • Glioblastoma / metabolism
  • Humans
  • Inhibitor of Apoptosis Proteins / metabolism*
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / therapeutic use*
  • Survivin

Substances

  • Antineoplastic Agents, Phytogenic
  • BIRC5 protein, human
  • Inhibitor of Apoptosis Proteins
  • Plant Extracts
  • Sesquiterpenes
  • Survivin
  • tagitinin