Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

Nature. 1990 Mar 15;344(6263):219-23. doi: 10.1038/344219a0.


Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • DNA-Binding Proteins / genetics*
  • Dosage Compensation, Genetic*
  • Drosophila / genetics*
  • Heterochromatin
  • Metalloproteins / genetics*
  • Molecular Sequence Data
  • Mutation
  • Phosphorylation
  • Pigmentation / genetics
  • Restriction Mapping
  • Suppression, Genetic


  • DNA-Binding Proteins
  • Heterochromatin
  • Metalloproteins
  • DNA