Combined measure of pro- and anti-oxidant exposures in relation to prostate cancer and colorectal adenoma risk: an update

Ann Epidemiol. 2010 Dec;20(12):955-7. doi: 10.1016/j.annepidem.2010.08.011.


Purpose: We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms - sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measures with systemic biomarkers of pro- and anti-oxidant exposures.

Methods: Low, medium and high pro-oxidant exposures, and high, medium and low antioxidant exposures were assigned 0, 1 and 2 points, respectively and individual points for all exposures were then summed to calculate the overall score. Case and controls were compared using logistic regression analysis after adjusting for covariates.

Results: When OBS was treated as a continuous variable the adjusted odds ratios and 95% confidence intervals (CI) for each additional score point were the same: 0.90 (95% CI: 0.83-0.97) for each study. When the OBS was divided into three approximately equal intervals, a comparison of the lowest to highest category showed similar adjusted ORs (95% CIs) of 0.34 (0.13-0.88) and 0.34 (0.14-0.86) for colorectal adenoma and prostate cancer, respectively.

Conclusions: Our analyses provide support for the stated hypothesis that combined measures of pro- and anti-oxidant exposures may be associated with oxidative stress-related conditions.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma* / pathology
  • Antioxidants / administration & dosage
  • Antioxidants / analysis*
  • Biomarkers / analysis*
  • Case-Control Studies
  • Colorectal Neoplasms / etiology*
  • Colorectal Neoplasms / pathology
  • Humans
  • Logistic Models
  • Male
  • Oxidative Stress*
  • Prostatic Neoplasms / etiology*
  • Reproducibility of Results
  • Risk Assessment / methods
  • Risk Factors
  • Smoking / epidemiology
  • Surveys and Questionnaires


  • Antioxidants
  • Biomarkers