CDDO-Im, an antitumor molecule that also improves platetet production

Leuk Res. 2011 Apr;35(4):427-8. doi: 10.1016/j.leukres.2010.10.011. Epub 2010 Nov 12.
No abstract available

Publication types

  • Comment
  • Editorial

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Blood Platelets / cytology
  • Blood Platelets / drug effects*
  • Blood Platelets / metabolism
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Erythroid Cells / cytology
  • Erythroid Cells / drug effects
  • Erythroid Cells / metabolism
  • GATA1 Transcription Factor / metabolism
  • GATA2 Transcription Factor / metabolism
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Imidazoles / pharmacology*
  • Megakaryocytes / cytology
  • Megakaryocytes / drug effects
  • Megakaryocytes / metabolism
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mitogen-Activated Protein Kinase 3 / metabolism
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / pharmacology
  • Signal Transduction / drug effects

Substances

  • 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole
  • Antineoplastic Agents
  • GATA1 Transcription Factor
  • GATA2 Transcription Factor
  • GATA2 protein, human
  • Imidazoles
  • Oleanolic Acid
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3