Anthrax toxins--roadblocks for exocytic trafficking

Keith Ireton

doi:10.1016/j.devcel.2010.10.019

Anthrax toxins--roadblocks for exocytic trafficking

Dev Cell. 2010 Nov 16;19(5):643-4. doi: 10.1016/j.devcel.2010.10.019.

Author

Keith Ireton¹

Affiliation

¹ Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand. keith.ireton@otago.ac.nz

PMID: 21074712
DOI: 10.1016/j.devcel.2010.10.019

Abstract

Anthrax toxins cause vascular dysfunction, in part by perturbing the endothelial cell barrier. Reporting in Nature, Guichard et al. shed new light on the mechanism by which this occurs and show that anthrax toxins interfere with exocytic delivery of cadherins to endothelial cell junctions by antagonizing the exocyst complex.

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