Bone invasion by Walker 256 carcinoma, line A in young and adult rats: effects of etidronate

Oncology. 1990;47(2):160-5. doi: 10.1159/000226810.


Line A of Walker 256 carcinoma implanted in the muscle adjacent to the tibia of young (6 weeks) and adult (9 months) male rats invaded the bone. Osteolysis and reactive growth were greater in the bone of young animals than in adults. Ethane-1-hydroxy-1, 1-bisphosphonate prevented bone lysis and tumor invasion of the cortex both in young and adult animals. This model may be useful for studies of age-related differences in tumor infiltration into the bone and for investigating drug effects on this process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Bone and Bones / drug effects
  • Bone and Bones / pathology*
  • Calcium / analysis
  • Carcinoma 256, Walker / pathology*
  • Etidronic Acid / pharmacology*
  • Male
  • Neoplasm Invasiveness
  • Rats
  • Rats, Inbred Strains


  • Etidronic Acid
  • Calcium