Clinical and immunological differences between early and late-onset myasthenia gravis in Japan

J Neuroimmunol. 2011 Jan;230(1-2):148-52. doi: 10.1016/j.jneuroim.2010.10.023. Epub 2010 Nov 12.


Immunological characteristics of myasthenia gravis (MG) with late-onset have not been fully elucidated. We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients. Sixty-two MG patients had thymoma. The others were divided into early-onset and late-onset groups separated by an age of 50 years. The ocular form was more frequent in late-onset compared to early-onset group. Seropositivity of anti-muscle-specific tyrosine kinase antibody was 2-3% in acetylcholine receptor-seronegative patients. HLA-DRB1 genotyping failed to detect statistical differences in specific alleles between each group and healthy controls. The immunological profiles in late-onset MG were different from early-onset in Japan.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aged
  • Autoantibodies / immunology*
  • Autoantigens / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Genotype
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Myasthenia Gravis / genetics*
  • Myasthenia Gravis / immunology*
  • Myasthenia Gravis / pathology*
  • Polymorphism, Restriction Fragment Length
  • Severity of Illness Index


  • Autoantibodies
  • Autoantigens
  • HLA-DR Antigens
  • HLA-DRB1 Chains