IL-17 and Th17 cells in tuberculosis

Cytokine Growth Factor Rev. 2010 Dec;21(6):455-62. doi: 10.1016/j.cytogfr.2010.10.004. Epub 2010 Nov 12.

Abstract

Tuberculosis is primarily a disease of the lung. Constant expression of cellular immunity in this organ is required to control Mycobacterium tuberculosis growth, but this can also result in chronic inflammation and pathologic consequences. During primary tuberculosis both IFN-γ and IL-17 are induced: both are potent inflammatory cytokines capable of inducing expression of chemokines that promote cell recruitment and granuloma organization throughout infection. During the chronic phase, a balance between Th1 and Th17 responses needs to be achieved to control bacterial growth and limit immunopathology, as a shift of the response towards excessive IL-17 production may sustain extensive neutrophil recruitment and tissue damage. Thus, regulation of Th1 and Th17 responses during tuberculosis is essential to promote anti-mycobacterial immunity and prevent extensive immunopathological consequences.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • BCG Vaccine / immunology
  • Cell Differentiation
  • Humans
  • Interferon-gamma / immunology
  • Interleukin-17 / immunology*
  • Interleukins / immunology
  • Lung / immunology
  • Mice
  • Th17 Cells / immunology*
  • Tuberculosis / immunology*
  • Tuberculosis / physiopathology

Substances

  • BCG Vaccine
  • Interleukin-17
  • Interleukins
  • Interferon-gamma
  • interleukin-22