Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from Ileal Crohn's disease biopsy tissue

J Bacteriol. 2011 Jan;193(2):583. doi: 10.1128/JB.01290-10. Epub 2010 Nov 12.


Escherichia coli UM146 was isolated from the ileum of a Crohn's disease patient. It adheres to and invades enterocytes and can replicate inside macrophages. Its complete genome sequence reveals that it is most closely related to the human urinary tract pathogen E. coli CFT073, but it has a host of genes that are novel and to which no function has been ascribed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Adhesion
  • Biopsy
  • Crohn Disease / microbiology*
  • DNA, Bacterial / chemistry*
  • DNA, Bacterial / genetics*
  • Enterocytes / microbiology
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification*
  • Genome, Bacterial*
  • Humans
  • Ileum / microbiology*
  • Macrophages / microbiology
  • Molecular Sequence Data
  • Sequence Analysis, DNA


  • DNA, Bacterial

Associated data

  • GENBANK/CP002167