Benzoyl peroxide: enhancing antibiotic efficacy in acne management

Skin Therapy Lett. Nov-Dec 2010;15(10):5-7.

Abstract

Benzoyl peroxide is one of the most widely used topical agents for acne. It has potent antibacterial and mild anti-inflammatory and comedolytic effects. To treat mild to moderate acne, it can be used alone or in combination with topical antibiotics and topical retinoids. The combination of benzoyl peroxide with either erythromycin or clindamycin is synergistic and well-tolerated. In more severe acne, when oral antibiotics are required, benzoyl peroxide can contribute to suppressing the emergence of resistant strains of Propionibacterium acnes.

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / microbiology
  • Administration, Cutaneous
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Benzoyl Peroxide / administration & dosage
  • Benzoyl Peroxide / adverse effects
  • Benzoyl Peroxide / therapeutic use*
  • Clindamycin / administration & dosage
  • Clindamycin / adverse effects
  • Clindamycin / therapeutic use
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / therapeutic use
  • Drug Resistance, Bacterial
  • Drug Synergism
  • Drug Therapy, Combination
  • Erythromycin / administration & dosage
  • Erythromycin / adverse effects
  • Erythromycin / therapeutic use
  • Humans
  • Severity of Illness Index

Substances

  • Anti-Bacterial Agents
  • Dermatologic Agents
  • Clindamycin
  • Erythromycin
  • Benzoyl Peroxide