Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi

J Basic Microbiol. 2011 Apr;51(2):120-8. doi: 10.1002/jobm.201000184. Epub 2010 Nov 12.


The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca(2+)-binding sites, and mediates the effects of cytosolic Ca(2+). Minute changes in free intracellular Ca(2+) are quickly transformed into changes in the activity of several kinases including calcium/calmodulin-dependent protein kinases (Ca(2+)/CaMKs) that are involved in regulating many eukaryotic cell functions. However, our current knowledge of NCS-1 and Ca(2+)/CaMKs comes mostly from studies of the mammalian enzymes. Thus far very few fungal homologues of NCS-1 and Ca(2+)/CaMKs have been characterized and little is known about their cellular roles. In this minireview, we describe the known sequences, interactions with target proteins and cellular roles of NCS-1 and Ca(2+)/CaMKs in fungi.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Calcium Signaling / physiology*
  • Calcium-Calmodulin-Dependent Protein Kinases / genetics
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • EF Hand Motifs / genetics
  • EF Hand Motifs / physiology
  • Fungi / enzymology
  • Fungi / genetics
  • Fungi / metabolism*
  • Molecular Sequence Data
  • Neuronal Calcium-Sensor Proteins / genetics
  • Neuronal Calcium-Sensor Proteins / metabolism*
  • Neuropeptides / genetics
  • Neuropeptides / metabolism*
  • Phylogeny
  • Sequence Alignment


  • Neuronal Calcium-Sensor Proteins
  • Neuropeptides
  • frequenin calcium sensor proteins
  • Calcium-Calmodulin-Dependent Protein Kinases