The clinical care of the HIV-1-infected infant

Clin Perinatol. 2010 Dec;37(4):873-85, xi. doi: 10.1016/j.clp.2010.08.002.


Despite well-established strategies to decrease the mother-to-child transmission of HIV-1, new perinatal infections continue to occur globally, reflecting marked disparities in access to health care. Once HIV-1 infection has been established in an infant, the combination of early initiation of antiretroviral therapy and prophylaxis against Pneumocystis jiroveci pneumonia is paramount to reducing disease progression. This article reviews the recommendations and evidence for the treatment of HIV-1-infected infants.

Publication types

  • Review

MeSH terms

  • Anti-Retroviral Agents / adverse effects
  • Anti-Retroviral Agents / therapeutic use
  • BCG Vaccine / therapeutic use
  • Breast Feeding / adverse effects
  • Child Development
  • Disease Progression
  • HIV Infections / drug therapy*
  • HIV Infections / physiopathology
  • HIV-1*
  • Humans
  • Infant
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Pneumocystis carinii
  • Pneumonia, Pneumocystis / prevention & control*
  • Population Surveillance
  • Vaccination


  • Anti-Retroviral Agents
  • BCG Vaccine