Immune responses after acute ischemic stroke or myocardial infarction

Int J Cardiol. 2012 Mar 22;155(3):372-7. doi: 10.1016/j.ijcard.2010.10.053. Epub 2010 Nov 13.


Background: We recently demonstrated an immediate immunodepressive state after acute ischemic stroke in humans.

Methods: In the present study, we prospectively analyzed immune responses in patients with middle cerebral artery stroke (n=20), acute myocardial infarction (n=20) and healthy controls (n=20, also matched for age and gender).

Results: Compared to controls, a rapid depression of monocytic HLA-DR expression and a defective lymphocytic IFN-γ production was obvious after ischemic stroke or myocardial infarction, while total counts of leukocytes and monocytes were significantly higher after myocardial infarction. A T cell-mediated lymphopenia was accentuated in patients with severe stroke, obviously predisposing these patients for nosocomial infections.

Conclusions: Our data reveal an immediate and to some extent differential suppression of cell-mediated immune responses after ischemic stroke or myocardial infarction respectively.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Ischemia / blood
  • Brain Ischemia / diagnosis
  • Brain Ischemia / immunology*
  • Cytokines / blood
  • Female
  • Follow-Up Studies
  • HLA-DR Antigens / blood
  • HLA-DR Antigens / immunology
  • Humans
  • Immune Tolerance*
  • Immunity, Cellular / immunology*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / immunology*
  • Prospective Studies
  • Stroke / immunology*
  • T-Lymphocytes / immunology*


  • Cytokines
  • HLA-DR Antigens