Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

Chem Commun (Camb). 2011 Jan 21;47(3):1057-9. doi: 10.1039/c0cc03624b. Epub 2010 Nov 15.

Abstract

A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

MeSH terms

  • Amidines / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
  • Heterocyclic Compounds, 4 or More Rings / chemistry

Substances

  • Amidines
  • Heterocyclic Compounds, 4 or More Rings
  • blebbistatin
  • Copper