CDR2 antigen and Yo antibodies

Cancer Immunol Immunother. 2011 Feb;60(2):283-9. doi: 10.1007/s00262-010-0943-9. Epub 2010 Nov 16.


Paraneoplastic cerebellar degeneration (PCD) is often associated with Yo antibodies that are directed against human cerebellar degeneration-related protein 2 (CDR2). Such antibodies may also be found in ovarian cancer patients without PCD. We studied if there was an association between Yo antibody production and differences in CDR2 cDNA sequence, mRNA or CDR2 expression in ovarian cancers. We found similar CDR2 cDNA sequence, mRNA and protein levels in primary ovarian cancers, with or without associated Yo antibodies. CDR2 was also present in other cancers, as well as in normal ovary tissue. The results suggest that Yo antibodies are not only related to the expression of CDR2 alone, but also to immune dysregulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies / analysis*
  • Antibodies / immunology*
  • Antigen-Antibody Complex / immunology
  • Female
  • Humans
  • Middle Aged
  • Nerve Tissue Proteins / analysis*
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / immunology*
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / immunology*
  • Paraneoplastic Cerebellar Degeneration / immunology
  • RNA, Messenger / genetics


  • Antibodies
  • Antigen-Antibody Complex
  • CDR2 protein, human
  • Nerve Tissue Proteins
  • RNA, Messenger