Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?

Sci Signal. 2010 Nov 16;3(148):pe43. doi: 10.1126/scisignal.3148pe43.


Endocytosis modulates the activities of members of a family of receptors known as Frizzled (Fz) proteins, which control canonical β-catenin signaling and the planar cell polarity pathway; however, what determines which of the two pathways is activated is unclear. Evidence now suggests that the guanosine triphosphatase Rab5, a key regulator of endocytosis, binds directly to Fz proteins and that subsequent trafficking steps determine the outcome of Fz signaling.

MeSH terms

  • Animals
  • Drosophila
  • Drosophila Proteins / metabolism*
  • Endocytosis
  • Frizzled Receptors / metabolism*
  • GTP-Binding Proteins / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction*
  • beta Catenin / metabolism*
  • rab5 GTP-Binding Proteins / metabolism*


  • Drosophila Proteins
  • Frizzled Receptors
  • Receptors, G-Protein-Coupled
  • beta Catenin
  • fz protein, Drosophila
  • GTP-Binding Proteins
  • rab5 GTP-Binding Proteins