Identification of dihydropyridines that reduce cellular tau levels

Chem Commun (Camb). 2011 Jan 7;47(1):529-31. doi: 10.1039/c0cc02253e. Epub 2010 Nov 16.

Abstract

A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Dihydropyridines / chemical synthesis
  • Dihydropyridines / chemistry*
  • Dihydropyridines / pharmacology
  • Humans
  • Molecular Structure
  • Oxidation-Reduction
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
  • tau Proteins / antagonists & inhibitors
  • tau Proteins / biosynthesis*

Substances

  • Dihydropyridines
  • tau Proteins
  • 1,4-dihydropyridine