[Photochemical internalisation (PCI): a further development of photodynamic therapy for the treatment of skin cancer]

Praxis (Bern 1994). 2010 Nov 17;99(23):1423-8. doi: 10.1024/1661-8157/a000310.
[Article in German]


Recently, several new and non-invasive methods have been introduced for the treatment of skin cancers. Topical creams using the immune modulator imiquimod or the COX inhibitor diclofenac (with hyaluronic acid) are now registered for use against neoplasms such as basal or squamous cell carcinoma. Another modern treatment option is photodynamic therapy (PDT). A refined version of PDT, namely photochemical internalisation, is currently subject to a first clinical trial in patients with osteosarcoma, squamous cell carcinoma, head and neck cancer as well as adenocarcinoma of the breast. Preliminary results from this trial suggest that PCI seems to be a promising treatment.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use
  • Carcinoma, Basal Cell / drug therapy*
  • Carcinoma, Squamous Cell / drug therapy*
  • Cytosol / drug effects
  • Endocytosis
  • Endosomes / drug effects
  • Humans
  • Melanoma / drug therapy*
  • Melanoma, Experimental / drug therapy
  • Mice
  • Neoplasm Transplantation
  • Photochemotherapy / methods*
  • Skin Neoplasms / drug therapy*


  • Antineoplastic Agents