Role of microRNAs in hematological malignancies

Expert Rev Hematol. 2009 Aug;2(4):415-23. doi: 10.1586/ehm.09.32.

Abstract

microRNAs (miRNAs) are short noncoding RNAs that function as post-transcriptional negative regulators of gene expression. They have been shown to be involved in the control of cell proliferation and differentiation, as well as acting as oncogenes or tumor-suppressor genes, suggesting their involvement in cancer development and progression. Expression profiles of human miRNAs have shown that many of them are aberrantly expressed in hematological malignancies. Therefore, miRNA profiling may be useful to distinguish between normal and tumor cells, and to create signatures for a variety of leukemia subtypes. Here, we review recent evidence for the involvement of miRNAs in the pathogenesis of different hematopoietic malignancies and their potential applications in diagnosis, prognosis and therapy of human leukemia.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Hematologic Neoplasms / genetics*
  • Hematologic Neoplasms / metabolism
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism

Substances

  • MicroRNAs