Serum 25-hydroxyvitamin D concentration and physical function in adult men

Clin Endocrinol (Oxf). 2011 Mar;74(3):370-6. doi: 10.1111/j.1365-2265.2010.03926.x.


Objective: Recent reports suggest that vitamin D status influences musculoskeletal health; yet, there are limited data in adult men. This study investigated whether serum 25-hydroxyvitamin D [25(OH)D] concentration was associated with lean body mass, muscle strength and physical performance in men.

Design: Population-based, observational survey.

Participants: 1219 black, Hispanic and white randomly selected men aged 30-79 years from the Boston Area Community Health/Bone Survey.

Measurements: Lean body mass by dual-energy X-ray absorptiometry, hand grip strength, a composite physical function score (chair stand and walking speed), 25(OH)D, parathyroid hormone (PTH), testosterone, age, race, body mass index, socioeconomic status, education, smoking, arthritis, self-reported health, calcium intake, physical activity.

Results: The distributions of serum 25(OH)D quartiles differed by race/ethnicity, education and smoking status. After adjustment for multiple lifestyle factors, serum 25(OH)D was not related to lean body mass, grip strength or the composite physical function score (all P>0.20). There was no variation in the associations between 25(OH)D level and outcomes by race/ethnicity. The relationship between PTH and the outcomes revealed similar results.

Conclusion: In this population-based sample of adult men with a broad age range, there was no association between serum 25(OH)D concentration and lean body mass, muscle strength and physical function after controlling for multiple lifestyle factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Absorptiometry, Photon
  • Adult
  • Aged
  • Black or African American / statistics & numerical data
  • Body Mass Index*
  • Boston
  • Hispanic or Latino / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Muscle Strength / physiology*
  • Parathyroid Hormone / blood
  • Psychomotor Performance / physiology*
  • Social Class
  • Testosterone / blood
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • White People / statistics & numerical data


  • Parathyroid Hormone
  • Vitamin D
  • Testosterone
  • 25-hydroxyvitamin D