NMR-determined lipoprotein subclass profile is associated with dietary composition and body size

Nutr Metab Cardiovasc Dis. 2011 Aug;21(8):603-9. doi: 10.1016/j.numecd.2009.12.003. Epub 2010 Nov 16.

Abstract

Background and aims: Dyslipidemia is influenced by diet and body habitus. The Nuclear Magnetic Resonance spectroscopy lipoprotein subclass profile (NMR-LSP) is associated with diabetes and its vascular complications; and an NMR-LSP featuring large VLDL particles and small LDL and HDL particles is linked with cardiovascular disease (CVD). Thus interventions which favourably modify NMR-LSP may reduce risk for diabetes, its complications and CVD. The study aim was to investigate the associations between NMR-LSP, dietary composition and body size measures using data from the Melbourne Collaborative Cohort Study (MCCS).

Methods and results: NMR-LSP was assessed in 313 men and 403 women (median age 54 years) randomly selected from a community-based cohort study. Diet was assessed using a specifically developed food frequency questionnaire (FFQ), and body size was assessed by body mass index (BMI) or waist:hips ratio (WHR). To simplify the 15 NMR-LSP variables, factor analysis was used to derive a single factor. Multivariate linear regression with this factor score as the dependent variable demonstrated that in men, total PUFA and n-6 dietary fat intake and BMI were associated with a more atherogenic NMR-LSP pattern; while in women dietary glycemic index and WHR demonstrated positive associations, and n-3 fat intake an inverse association.

Conclusions: We developed a single factor score to summarize the NMR-LSP that has the benefit of combining all aspects of the NMR-LSP and accounting for correlations between them. We have shown correlations between the NMR-LSP and body size and dietary composition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Body Composition
  • Body Mass Index
  • Body Size*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cholesterol, VLDL / chemistry*
  • Cross-Sectional Studies
  • Diet*
  • Female
  • Humans
  • Linear Models
  • Magnetic Resonance Spectroscopy*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Prospective Studies
  • Surveys and Questionnaires
  • Waist-Hip Ratio

Substances

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Cholesterol, VLDL