Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs

J Bras Pneumol. 2010 Sep-Oct;36(5):641-56. doi: 10.1590/s1806-37132010000500017.
[Article in English, Portuguese]


The main objectives of tuberculosis therapy are to cure the patients and to minimize the possibility of transmission of the bacillus to healthy subjects. Adverse effects of antituberculosis drugs or drug interactions (among antituberculosis drugs or between antituberculosis drugs and other drugs) can make it necessary to modify or discontinue treatment. We describe the general mechanism of action, absorption, metabolization, and excretion of the drugs used to treat multidrug resistant tuberculosis (aminoglycosides, fluoroquinolones, cycloserine/terizidone, ethionamide, capreomycin, and para-aminosalicylic acid). We describe adverse drug reactions and interactions (with other drugs, food, and antacids), as well as the most appropriate approach to special situations, such as pregnancy, breastfeeding, liver failure, and kidney failure.

Publication types

  • Review

MeSH terms

  • Antitubercular Agents / adverse effects
  • Antitubercular Agents / pharmacokinetics
  • Antitubercular Agents / therapeutic use*
  • Drug Interactions
  • Female
  • Food-Drug Interactions
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Tuberculosis / drug therapy*
  • Tuberculosis, Multidrug-Resistant / drug therapy


  • Antitubercular Agents