Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design

Expert Rev Vaccines. 2010 Nov;9(11):1315-24. doi: 10.1586/erv.10.118.

Abstract

Influenza A virus is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. It has become increasingly evident that influenza viral infection is recognized by at least three classes of pattern-recognition receptors, including TLR-7, the retinoic acid inducible gene-I and nucleotide-binding domain and leucine-rich-repeat-containing protein 3, a member of the Nod-like receptor family. This article highlights the roles of different types of innate immune receptors in influenza virus immunity versus immunopathology.

Publication types

  • Review

MeSH terms

  • Carrier Proteins / immunology*
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / immunology*
  • Humans
  • Immunity, Innate
  • Influenza A virus / immunology*
  • Influenza Vaccines / immunology*
  • Influenza, Human / immunology*
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Receptors, Immunologic
  • Toll-Like Receptor 7 / immunology*

Substances

  • Carrier Proteins
  • Influenza Vaccines
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Receptors, Immunologic
  • TLR7 protein, human
  • Toll-Like Receptor 7
  • RIGI protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases