A longitudinal assessment of painful diabetic peripheral neuropathy on health status, productivity, and health care utilization and cost

Pain Med. 2011 Jan;12(1):118-26. doi: 10.1111/j.1526-4637.2010.01012.x. Epub 2010 Nov 18.


Objective: The aim of the current study was to examine the health outcomes of patients suffering from painful diabetic peripheral neuropathy (pDPN) over a 3-year period, relative to patients with diabetes but without neuropathic pain and controls.

Design: The current study included participants who completed three consecutive waves of the National Health and Wellness Survey (2006-2008). These participants were categorized into one of three groups: those with pDPN (N=290), those with diabetes but without pDPN ("diabetes without pDPN group"; N=1,037), and those not diagnosed with diabetes ("control group"; N=8,162).

Outcome measures: Health status (Short Form-12v2), work productivity (Work Productivity and Activity Impairment Questionnaire), and resource use were examined with repeated-measures models adjusting for demographic and clinical factors.

Results: The pDPN group reported significantly lower levels of physical quality of life. Moreover, physical quality of life scores for the pDPN group decreased at a significantly faster rate over a 3-year period relative to other groups. In addition, the pDPN patients reported significantly higher levels of impairment of work productivity and activity, greater resource use, and higher total 3-year per-patient costs.

Conclusions: Confirming and expanding upon the literature, our results indicate a significantly worse trajectory of quality of life outcomes over time and long-term increased total costs for pDPN patients relative to non-pDPN diabetes patients and controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Body Mass Index
  • Cost of Illness*
  • Delivery of Health Care / economics*
  • Delivery of Health Care / statistics & numerical data*
  • Diabetes Mellitus, Type 2 / economics
  • Diabetic Neuropathies / economics*
  • Diabetic Neuropathies / epidemiology*
  • Diabetic Neuropathies / psychology
  • Efficiency
  • Employment
  • Exercise / physiology
  • Female
  • Health Status
  • Health Surveys
  • Hospitalization / economics
  • Humans
  • Income
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • United States / epidemiology