Streptomyces turgidiscabies Car8 contains a modular pathogenicity island that shares virulence genes with other actinobacterial plant pathogens

Plasmid. 2011 Mar;65(2):118-24. doi: 10.1016/j.plasmid.2010.11.002. Epub 2010 Nov 16.


Streptomyces turgidiscabies Car8 is an actinobacterium that causes the economically important disease potato scab. Pathogenesis in this species is associated with a mobile pathogenicity island (PAISt) that site specifically inserts into the bacA gene in Streptomyces spp. Here we provide the 674,223 bp sequence of PAISt, which consists of two non-overlapping modules of 105,364 and 568,859 bp. These modules are delimited by three copies of an 8 bp palindromic sequence (TTCATGAA), that also is the integration site (att) of the element. Putative tyrosine recombinase (IntSt) and excisionase (XisSt) proteins are encoded just upstream of att-R. PAISt has regions of synteny to pathogenic, symbiotic and saprophytic actinomycetes. The 105,364 bp PAISt module is identical to a genomic island in Streptomyces scabies 87-22, while the 568,859 bp module contains only a short region of synteny to that genome. However, both modules contain previously characterized and candidate virulence genes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • Computational Biology
  • DNA Nucleotidyltransferases / metabolism
  • Gene Order
  • Genes, Bacterial / genetics
  • Genomic Islands*
  • Integrases / metabolism
  • Molecular Sequence Annotation
  • Molecular Sequence Data
  • Recombination, Genetic
  • Solanum tuberosum / microbiology
  • Streptomyces / enzymology
  • Streptomyces / genetics*
  • Streptomyces / pathogenicity*
  • Synteny / genetics
  • Tyrosine / metabolism
  • Viral Proteins / metabolism
  • Virulence / genetics*


  • Viral Proteins
  • Tyrosine
  • DNA Nucleotidyltransferases
  • Integrases
  • excisionase