A case of phospholipase A₂ receptor-positive membranous nephropathy preceding sarcoid-associated granulomatous tubulointerstitial nephritis

Am J Kidney Dis. 2011 Jan;57(1):140-3. doi: 10.1053/j.ajkd.2010.09.015. Epub 2010 Nov 17.


We report the case of a 29-year-old man with membranous nephropathy that was associated with a sarcoidosic granulomatous tubulointerstitial nephritis, but was without an apparent calcium metabolism disorder. Corticosteroid treatment was associated with remission of nephrotic syndrome. We discuss the relationship between membranous nephropathy and sarcoidosis based on the close appearance of the 2 diseases and the detection of phospholipase A₂ receptor in glomerular immune deposits.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Glomerulonephritis, Membranous / complications*
  • Glomerulonephritis, Membranous / diagnosis
  • Glomerulonephritis, Membranous / metabolism
  • Granuloma / complications*
  • Granuloma / diagnosis
  • Humans
  • Kidney Glomerulus / metabolism
  • Male
  • Nephritis, Interstitial / complications*
  • Nephritis, Interstitial / diagnosis
  • Receptors, Phospholipase A2 / analysis*
  • Sarcoidosis / complications*
  • Sarcoidosis / diagnosis


  • Receptors, Phospholipase A2