Resistance status and evolution trends of Klebsiella pneumoniae isolates in a university hospital in Greece: ineffectiveness of carbapenems and increasing resistance to colistin

Chemotherapy. 2010;56(6):448-52. doi: 10.1159/000320943. Epub 2010 Nov 18.


Background: Due to its increased non-susceptibility rates, Klebsiella pneumoniae has emerged as one of the most problematic pathogens.

Methods: The level of resistance to 25 antimicrobials of K. pneumoniae isolates from a teaching hospital in Greece and the evolution trends during 2 decades were examined.

Results: A statistically significant increase in non-susceptibility rates was found for almost all antimicrobials examined. During 2008, the isolates presented non-susceptibility rates to aminoglycosides >50% and to quinolones >60%. Nowadays, 1 out of 10 isolates is non-susceptible to colistin. Moreover, the isolates non-susceptible to imipenem were almost doubled between 2007 (29%) and 2008 (50%). Among the imipenem-resistant isolates, 1 out of 4 was also resistant to colistin.

Conclusion: The effectiveness of carbapenems has been compromised and the increase in resistance to colistin is rapid and steep.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Carbapenems / pharmacology*
  • Carbapenems / therapeutic use
  • Colistin / pharmacology*
  • Colistin / therapeutic use
  • Drug Resistance, Multiple, Bacterial / physiology
  • Greece / epidemiology
  • Hospitals, University
  • Humans
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / epidemiology
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / isolation & purification*
  • Microbial Sensitivity Tests


  • Anti-Bacterial Agents
  • Carbapenems
  • Colistin