Heat shock proteins are important mediators of skeletal muscle insulin sensitivity

Exerc Sport Sci Rev. 2011 Jan;39(1):34-42. doi: 10.1097/JES.0b013e318201f236.


Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / prevention & control
  • Heat-Shock Proteins / metabolism*
  • Hot Temperature
  • Humans
  • Insulin / metabolism
  • Insulin Resistance*
  • Muscle, Skeletal / metabolism*
  • Oxidative Stress


  • Heat-Shock Proteins
  • Insulin