The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs

Nat Rev Immunol. 2010 Dec;10(12):813-25. doi: 10.1038/nri2886. Epub 2010 Nov 19.


T cells encounter their cognate antigens in specialized compartments of secondary lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T cells, and promote immunity or tolerance depending on the availability of danger signals. Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting them to T cell zones and guiding their migration within SLOs. Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology*
  • Antigens / immunology
  • Cell Movement / immunology
  • Hematopoietic System / immunology*
  • Humans
  • Immune Tolerance
  • Lymphoid Tissue / immunology*
  • Mice
  • Stromal Cells / immunology
  • T-Lymphocytes / immunology


  • Antigens