Chromatographic studies on the binding, action and metabolism of (-)-deprenyl

J Chromatogr. 1990 Jan 19;499:589-99. doi: 10.1016/s0021-9673(00)97003-1.

Abstract

Serum binding, the effect on striatal dopamine release and the metabolism of (-)-deprenyl [N-methyl-N-propargyl(2-phenyl-1-methyl)ethylammonium chloride], TZ-650 [N-methyl-N-propargyl(2-phenyl)ethylammonium chloride] and J-508 [N-methyl-N-propargyl(indanyl)ammonium chloride] were investigated using various chromatographic methods. A strong interaction between (-)-deprenyl and macroglobulins was found. Deprenyl enhanced the dopamine release from striatal slices of the rat brain and also inhibited the dopamine-DOPAC conversion. Deprenyl analogues showed either smaller or no effect. Hydroxylation of (-)-deprenyl takes place in the para position, in addition to the usual oxidative N-dealkylations, which are known from various metabolic studies on N-substituted phenylalkylamines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography / methods*
  • Female
  • Male
  • Parkinson Disease / drug therapy
  • Phenethylamines / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Selegiline / analysis
  • Selegiline / metabolism*
  • Selegiline / therapeutic use

Substances

  • Phenethylamines
  • Selegiline