Diagnosis of ocular sarcoidosis

Ocul Immunol Inflamm. 2010 Dec;18(6):432-41. doi: 10.3109/09273948.2010.524344.


Introduction: Sarcoidosis is a chronic inflammatory disorder with an unknown etiology characterized by noncaseating granulomas. The disorder is a multisystemic disease and affects many organs, including most often the lung, lymph nodes, skin, heart, liver, muscles, and the eye.

Material and methods: [corrected] Based on a review of the literature and on an algorithm generated in an international workshop on sarcoidosis, this article provides the reader with a schematic and simple approach to the diagnosis of ocular sarcoidosis.

Conclusions: In a considerable proportion of cases it is the ophthalmologist who first sees patients presenting with the ocular expression of sarcoidosis. In countries where the incidence of sarcoidosis is common, like Japan, a complete workup should be performed, whereas in countries where the incidence of the disease is less high, a noninvasive approach may be warranted at first.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Choroid Diseases / diagnosis
  • Coloring Agents
  • Diagnosis, Differential
  • Eye Diseases / diagnosis*
  • Eye Diseases / epidemiology
  • Eye Neoplasms / diagnosis
  • Fluorescein Angiography
  • Granuloma / diagnosis
  • Humans
  • Incidence
  • Indocyanine Green
  • Iritis / diagnosis
  • Lymphatic Diseases / diagnosis
  • Lymphoma / diagnosis
  • Lymphoproliferative Disorders / diagnosis
  • Magnetic Resonance Imaging
  • Phlebitis / diagnosis
  • Retinal Diseases / diagnosis
  • Sarcoidosis / diagnosis*
  • Sarcoidosis / epidemiology
  • Uveomeningoencephalitic Syndrome / diagnosis


  • Coloring Agents
  • Indocyanine Green