Mycoplasmas in Pregnancy

BJOG. 2011 Jan;118(2):164-74. doi: 10.1111/j.1471-0528.2010.02766.x. Epub 2010 Nov 23.

Abstract

The genital mycoplasmas have been implicated in a number of adverse outcomes of pregnancy. Spontaneous preterm labour and preterm birth is an important contributor to perinatal mortality and morbidity. If Mycoplasma hominis plays an integral part in this problem, it is likely to contribute through its involvement with bacterial vaginosis. Ureaplasmas induce cytokines and inflammation, making a casual association compelling. The role of Mycoplasma genitalium and Mycoplasma fermentans is less clear, but M. genitalium is potentially pathogenic and should be treated if detected. There is considerable evidence for the role of M. hominis in post-partum and post-abortal sepsis, and for ureaplasmas causing chronic lung disease or death in very low birthweight infants. The role of the genital mycoplasmas in adverse outcomes of pregnancy is complicated by the presence or absence of bacterial vaginosis, and this association requires further research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abortion, Spontaneous / microbiology
  • Female
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature, Diseases / microbiology
  • Mycoplasma Infections / complications*
  • Mycoplasma Infections / drug therapy
  • Mycoplasma genitalium*
  • Obstetric Labor, Premature / microbiology*
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Complications, Infectious / microbiology*
  • Pregnancy Outcome
  • Pregnancy, Ectopic / microbiology
  • Vaginosis, Bacterial / complications*