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Review
. 2010 Dec;68 Suppl 2:S112-8.
doi: 10.1111/j.1753-4887.2010.00346.x.

B Vitamins and the Aging Brain

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Review

B Vitamins and the Aging Brain

Jacob Selhub et al. Nutr Rev. .

Abstract

Deficiencies of the vitamins folate, B(12) , and B(6) are associated with neurological and psychological dysfunction and with congenital defects. In the elderly, cognitive impairment and incident dementia may be related to the high prevalence of inadequate B vitamin status and to elevations of plasma homocysteine. Plausible mechanisms include homocysteine neurotoxicity, vasotoxicity, and impaired S-adenosylmethionine-dependent methylation reactions vital to central nervous system function. In light of this, it is imperative to find safe ways of improving vitamin B status in the elderly without exposing some individuals to undue risk.

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