New mechanisms and functions of actin nucleation

Curr Opin Cell Biol. 2011 Feb;23(1):4-13. doi: 10.1016/ Epub 2010 Nov 17.


In cells the de novo nucleation of actin filaments from monomers requires actin-nucleating proteins. These fall into three main families--the Arp2/3 complex and its nucleation promoting factors (NPFs), formins, and tandem-monomer-binding nucleators. In this review, we highlight recent advances in understanding the molecular mechanism of actin nucleation by both well-characterized and newly identified nucleators, and explore current insights into their cellular functions in membrane trafficking, cell migration and division. The mechanisms and functions of actin nucleators are proving to be more complex than previously considered, with extensive cooperation and overlap in their cellular roles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / chemistry
  • Actin Cytoskeleton / metabolism*
  • Actins / chemistry
  • Actins / metabolism*
  • Animals
  • Cell Division
  • Cell Movement
  • Cells / cytology
  • Cells / metabolism
  • Humans
  • Models, Biological


  • Actins