Is there any association between esophagogastric endoscopic findings and laryngeal cancer?

Am J Otolaryngol. Nov-Dec 2011;32(6):490-3. doi: 10.1016/j.amjoto.2010.09.013. Epub 2010 Nov 20.


Purpose: The aim of the study was to survey the association between prevalence of acid-related inflammation in the upper digestive tract and laryngeal cancer.

Materials and methods: A case-control study was done in an otolaryngology ward at an academic university. Totally, 65 patients with laryngeal cancer and 65 cancer-free matched controls underwent esophagogastroduodenoscopy, and endoscopic findings were collected.

Results: In the case group, positive endoscopic findings were significantly higher than the control group (87.7% vs 58.5%; P < .001). Laryngeal cancer patients had erosive esophagitis, and gastritis ± other findings more than the control group (48 vs 29 cases) and the difference was statistically significant.

Conclusion: The difference between endoscopic findings in cases and controls was statistically significant. Severe inflammation and erosion existed in patients with laryngeal cancer that could be due to increased acid secretion. Our study supported the hypothesis that gastric acid and pepsin play a role in laryngeal cancer.

Publication types

  • Comparative Study

MeSH terms

  • Age Distribution
  • Case-Control Studies
  • Comorbidity
  • Esophagitis, Peptic / diagnosis
  • Esophagitis, Peptic / epidemiology*
  • Esophagoscopy / methods
  • Female
  • Gastric Acid / metabolism*
  • Gastritis / diagnosis
  • Gastritis / epidemiology
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / epidemiology*
  • Gastroscopy / methods
  • Humans
  • Hydrogen-Ion Concentration
  • Incidence
  • Laryngeal Neoplasms / diagnosis
  • Laryngeal Neoplasms / epidemiology*
  • Male
  • Middle Aged
  • Peptic Ulcer / diagnosis
  • Peptic Ulcer / epidemiology*
  • Prognosis
  • Reference Values
  • Risk Assessment
  • Sex Distribution