Chaperone-mediated autophagy in protein quality control

Curr Opin Cell Biol. 2011 Apr;23(2):184-9. doi: 10.1016/ Epub 2010 Nov 18.


Chaperone-mediated autophagy is a selective mechanism for degradation of soluble cytosolic proteins in lysosomes that distinguishes itself from other autophagic pathways by the selectivity with which CMA substrates are targeted for degradation. The recent molecular dissection of this autophagic pathway and the development of experimental models with compromised CMA have unveiled the important contribution of this pathway to protein quality control. In fact, CMA activation seems to be a common mechanism of cellular defense against proteotoxicity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy*
  • Humans
  • Lysosomes / metabolism
  • Molecular Chaperones / metabolism*
  • Proteins / metabolism


  • Molecular Chaperones
  • Proteins