A double-blind, placebo-controlled study of the efficacy of Lactinex in the prophylaxis of amoxicillin-induced diarrhea

DICP. 1990 Apr;24(4):382-4. doi: 10.1177/106002809002400408.


The disruption of the natural flora of the gastrointestinal tract (especially Lactobacillus acidophilus) may occur during antibiotic therapy. This may lead to diarrhea, dehydration, and electrolyte imbalances. It has been suggested that replacement of the lactobacilli with a commercially available product may prevent the diarrhea. The efficacy and safety of prophylactically administered Lactinex (culture of L. acidophilus and L. bulgaricus) was compared with placebo for the prevention of amoxicillin-induced diarrhea in pediatric patients. Lactinex or placebo was administered four times a day for ten days to coincide with the antibiotic therapy. The Lactobacillus preparation did not appear to consistently prevent diarrhea in this patient population. Patients' age, diet, and parental definition of diarrhea were factors that may have influenced the results.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amoxicillin / adverse effects*
  • Biological Products / adverse effects
  • Biological Products / therapeutic use*
  • Child, Preschool
  • Diarrhea / chemically induced
  • Diarrhea / microbiology
  • Diarrhea / prevention & control*
  • Double-Blind Method
  • Humans
  • Infant
  • Lactobacillus acidophilus / drug effects
  • Randomized Controlled Trials as Topic


  • Biological Products
  • lactinex
  • Amoxicillin