Trapped versus soluble chemokines: functions in leukocyte adhesion and motility

Immunity. 2010 Nov 24;33(5):654-6. doi: 10.1016/j.immuni.2010.11.012.

Abstract

In this issue of Immunity, Bao et al. (2010) provide in vivo evidence that heparan sulfate glycosaminoglycans (GAGs) are indispensable for immobilization and function of major chemokines required for leukocyte adhesion to and crossing through blood and lymphatic vessels.

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