Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity

Exp Toxicol Pathol. 2012 Jul;64(5):449-52. doi: 10.1016/j.etp.2010.10.012. Epub 2010 Nov 20.


The present study examines the preventive role of hesperidin (HDN) on plasma, cardiac and hepatic lipids in isoproterenol (ISO)-induced rats. Myocardial injury was induced by subcutaneous injection of isoproterenol hydrochloride (85 mg/kg BW) twice at an interval of 24 h, for two consecutive days. HDN was administered by post-orally at a dose of 200 mg/kg BW. The results showed increased levels of plasma cholesterol, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL) and decreased level of high density lipoprotein-cholesterol (HDL-C) in ISO-induced rats. ISO rats also showed an increase in cholesterol, TG and FFA and decrease in PL levels in the heart and liver tissues. HDN treatment brought the above parameters towards normal level. This experiment shows that HDN possesses hypolipidemic effect in ISO-induced rats.

MeSH terms

  • Animals
  • Cardiotonic Agents / toxicity
  • Disease Models, Animal
  • Heart / drug effects*
  • Hesperidin / pharmacology*
  • Isoproterenol / toxicity
  • Lipid Metabolism / drug effects
  • Lipids / analysis*
  • Lipids / blood
  • Liver / drug effects*
  • Male
  • Myocardial Ischemia / chemically induced
  • Myocardial Ischemia / metabolism*
  • Rats
  • Rats, Wistar


  • Cardiotonic Agents
  • Lipids
  • Hesperidin
  • Isoproterenol