A new and efficient synthetic route for the anxiolytic agent CL285032

Bioorg Med Chem Lett. 2011 Jan 1;21(1):259-61. doi: 10.1016/j.bmcl.2010.11.017. Epub 2010 Nov 5.

Abstract

CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Anxiety Agents / chemical synthesis*
  • Anti-Anxiety Agents / chemistry
  • Anti-Anxiety Agents / therapeutic use
  • Dogs
  • Phobic Disorders / drug therapy
  • Pyridazines / chemical synthesis*
  • Pyridazines / chemistry
  • Pyridazines / therapeutic use

Substances

  • Anti-Anxiety Agents
  • CL285032
  • Pyridazines
  • pyridazine