Diabetic gastroparesis and its impact on glycemia

Endocrinol Metab Clin North Am. 2010 Dec;39(4):745-62. doi: 10.1016/j.ecl.2010.08.007.


Diabetes is the most common cause of gastroparesis and it is now recognized that the relationship between gastric emptying and glycemia is complex and intertwined. Postprandial blood glucose levels influence, and are influenced by, the rate of gastric emptying, highlighting the difficulty in determining which is the cause and which is the effect. Novel diagnostic techniques and therapeutic strategies have been developed for the management of diabetic gastroparesis. This article highlights recent advances in knowledge about diabetic gastroparesis, with an emphasis on the inter-relationships between disordered gastric motor function on glycemia and vice versa, as well as therapeutic strategies for optimizing glycemic control using modulation of gastric emptying.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Glucose / metabolism*
  • Diabetes Mellitus / physiopathology
  • Diabetic Neuropathies / blood
  • Diabetic Neuropathies / complications*
  • Diabetic Neuropathies / diagnosis
  • Diabetic Neuropathies / epidemiology
  • Gastric Emptying / physiology
  • Gastroparesis / blood
  • Gastroparesis / complications*
  • Gastroparesis / diagnosis
  • Gastroparesis / epidemiology
  • Humans
  • Hypoglycemia / etiology
  • Hypoglycemia / therapy
  • Hypotension / etiology
  • Hypotension / therapy
  • Postprandial Period / physiology


  • Blood Glucose