A computational model of direct brain stimulation by electroconvulsive therapy

Annu Int Conf IEEE Eng Med Biol Soc. 2010:2010:2069-72. doi: 10.1109/IEMBS.2010.5626333.

Abstract

Electroconvulsive therapy (ECT) is the most effective treatment for severe depressive disorder, and yet the mechanisms of its therapeutic effects remain largely unknown. A novel computational model is presented in this study to simulate and investigate direct cortical excitation caused by bitemporal electroconvulsive therapy (BT ECT), using a finite element model (FEM) of the human head. The skull was modeled with anisotropic conductivity, with an excitable ionic neural model incorporated into the brain based on the classic Hodgkin-Huxley formulation. Results suggested that this model is able to reproduce direct stimulation of the cortex during the application of ECT.

MeSH terms

  • Algorithms
  • Anisotropy
  • Cerebral Cortex / pathology
  • Cerebrospinal Fluid / metabolism
  • Computer Simulation
  • Deep Brain Stimulation / instrumentation
  • Deep Brain Stimulation / methods
  • Electric Conductivity
  • Electroconvulsive Therapy / instrumentation*
  • Electroconvulsive Therapy / methods*
  • Electrodes
  • Finite Element Analysis
  • Head / pathology*
  • Humans
  • Membrane Potentials
  • Models, Theoretical
  • Skull / pathology