A closed-loop brain computer interface for real-time seizure detection and control

Annu Int Conf IEEE Eng Med Biol Soc. 2010:2010:4950-3. doi: 10.1109/IEMBS.2010.5627243.


The worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by available therapies. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. In this paper, a portable closed-loop brain computer interface for seizure control was developed and shown with several aspects of advantages, including high seizure detection rate (92-99% during wake-sleep states), low false detection rate (1.2-2.5%), and small size. The seizure detection and electrical stimulation latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. Experimental data from freely moving rats supported the functional possibility of a real-time closed-loop seizure controller.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biofeedback, Psychology / instrumentation*
  • Computer Systems
  • Deep Brain Stimulation / instrumentation*
  • Electroencephalography / instrumentation*
  • Equipment Design
  • Equipment Failure Analysis
  • Rats
  • Seizures / diagnosis*
  • Seizures / prevention & control*
  • Signal Processing, Computer-Assisted / instrumentation
  • Therapy, Computer-Assisted / methods*
  • User-Computer Interface*