PCRPi-DB: a database of computationally annotated hot spots in protein interfaces

Nucleic Acids Res. 2011 Jan;39(Database issue):D755-60. doi: 10.1093/nar/gkq1068. Epub 2010 Nov 18.


Protein-protein interactions are central to almost any cellular process. Although typically protein interfaces are large, it is well established that only a relatively small region, the so-called 'hot spot', contributes the most to the total binding energy. There is a clear interest in identifying hot spots because of its application in drug discovery and protein design. Presaging Critical Residues in Protein Interfaces Database (PCRPi-DB) is a public repository that archives computationally annotated hot spots in protein complexes for which the 3D structure is known. Hot spots have been annotated using a new and highly accurate computational method developed in the lab. PCRPi-DB is freely available to the scientific community at http://www.bioinsilico.org/PCRPIDB. Besides browsing and querying the contents of the database, extensive documentation and links to relevant on-line resources and contents are available to users. PCRPi-DB is updated on a weekly basis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Bacterial Proteins / chemistry
  • Computational Biology
  • Databases, Protein*
  • Molecular Sequence Annotation
  • Multiprotein Complexes / chemistry*
  • Protein Conformation
  • Protein Interaction Mapping*
  • beta-Lactamases / chemistry


  • Bacterial Proteins
  • Multiprotein Complexes
  • beta-lactamase-inhibitor protein, Streptomyces
  • beta-Lactamases
  • beta-lactamase TEM-1