Murine trophoblast cells are not killed by tumor necrosis factor-alpha

J Reprod Immunol. 1990 Mar;17(1):93-9. doi: 10.1016/0165-0378(90)90043-6.

Abstract

Purified midgestation murine trophoblast cannot be killed by a variety of cell-mediated effector mechanisms, with the exception of highly lytic effectors such as lymphokine-activated killer cells. We now report that this trophoblast population is also resistant to tumor necrosis factor (TNF)-alpha.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Animals
  • Cycloheximide / pharmacology
  • Cytotoxins / pharmacology
  • Dactinomycin / pharmacology
  • In Vitro Techniques
  • Interferon-gamma / pharmacology
  • Mice
  • Trophoblasts / physiology*
  • Tumor Necrosis Factor-alpha / pharmacology*

Substances

  • Cytotoxins
  • Tumor Necrosis Factor-alpha
  • Dactinomycin
  • Interferon-gamma
  • Cycloheximide