Abstract
The aim of this study was to investigate the effect of β tricalcium phosphate (β-TCP) particle size on recombinant human platelet-derived growth factor-BB (rhPDGF-BB)-induced regeneration of periodontal tissue in dog. The control group (rhPDGF-BB alone) was characterized by incomplete, newly formed bone. The large-particle β-TCP (L-TCP(O))/rhPDGF-BB group showed a statistically significant increase in both new bone and cementum formation compared to the small-particle β-TCP (S-TCP(G))/rhPDGF-BB group. These findings suggest that L-TCP(O)-particle promotes rhPDGF-BB-induced formation of bone and cementum.
MeSH terms
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Acid Phosphatase / analysis
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Alveolar Bone Loss / surgery*
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Alveolar Process / pathology
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Angiogenesis Inducing Agents / therapeutic use*
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Animals
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Becaplermin
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Biocompatible Materials / chemistry
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Biocompatible Materials / therapeutic use*
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Biomarkers / analysis
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Bone Regeneration / drug effects
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Bone Substitutes / chemistry
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Bone Substitutes / therapeutic use*
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Calcium Phosphates / chemistry
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Calcium Phosphates / therapeutic use*
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Cementogenesis / drug effects
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Dental Cementum / pathology
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Dogs
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Fibroblasts / pathology
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Giant Cells / pathology
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Humans
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Image Processing, Computer-Assisted
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Isoenzymes / analysis
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Male
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Microscopy, Electron, Scanning
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Osteogenesis / drug effects
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Particle Size
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Platelet-Derived Growth Factor / therapeutic use*
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Porosity
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Proto-Oncogene Proteins c-sis
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Random Allocation
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Recombinant Proteins
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Surgical Flaps
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Tartrate-Resistant Acid Phosphatase
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X-Ray Diffraction
Substances
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Angiogenesis Inducing Agents
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Biocompatible Materials
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Biomarkers
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Bone Substitutes
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Calcium Phosphates
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Isoenzymes
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Platelet-Derived Growth Factor
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Proto-Oncogene Proteins c-sis
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Recombinant Proteins
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beta-tricalcium phosphate
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Becaplermin
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Acid Phosphatase
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Tartrate-Resistant Acid Phosphatase