LKB1 regulated pathways in lung cancer invasion and metastasis

J Thorac Oncol. 2010 Dec;5(12):1883-6. doi: 10.1097/JTO.0b013e3181fbc28a.

Abstract

Metastasis is characterized by the ability of cancer cells to invade into adjacent tissue, intravasate into blood or lymphatic vessels, and extravasate into a distant tissue. Metastatic disease is primarily responsible for the low 5-year survival rate of non-small cell lung cancer (NSCLC), and therefore, an understanding of the molecular mechanisms that regulate NSCLC metastasis is clearly warranted. The serine/threonine kinase and tumor suppressor LKB1 is mutated in 30% of NSCLC tumors, and recent evidence points to a prominent role in NSCLC metastasis. This review summarizes LKB1-dependent invasion pathways where compromised LKB1 function could promote NSCLC metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases / physiology
  • Anoikis
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Cell Adhesion
  • Cell Polarity
  • Humans
  • Lung Neoplasms / pathology*
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Protein-Serine-Threonine Kinases / physiology*
  • Signal Transduction / physiology*

Substances

  • STK11 protein, human
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases