A common origin of synaptic vesicles undergoing evoked and spontaneous fusion

Nat Neurosci. 2010 Dec;13(12):1451-3. doi: 10.1038/nn.2695.


There is a longstanding controversy on the identity of synaptic vesicles undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested that spontaneous release is driven by a resting pool of synaptic vesicles refractory to stimulation. We found that cross-depletion of spontaneously or actively recycling synaptic vesicle pools occurred on stimulation in rat hippocampal neurons and identified the recycling pool as a major source of spontaneous release.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Endocytosis / physiology*
  • Evoked Potentials / physiology*
  • Hippocampus / metabolism
  • Membrane Fusion / physiology*
  • Rats
  • Rats, Wistar
  • Synaptic Transmission / physiology*
  • Synaptic Vesicles / metabolism*