MET Signalling: Principles and Functions in Development, Organ Regeneration and Cancer

Nat Rev Mol Cell Biol. 2010 Dec;11(12):834-48. doi: 10.1038/nrm3012.

Abstract

The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue remodelling, which underlies developmental morphogenesis, wound repair, organ homeostasis and cancer metastasis, by integrating growth, survival and migration cues in response to environmental stimuli or cell-autonomous perturbations. The versatility of MET-mediated biological responses is sustained by qualitative and quantitative signal modulation. Qualitative mechanisms include the engagement of dedicated signal transducers and the subcellular compartmentalization of MET signalling pathways, whereas quantitative regulation involves MET partnering with adaptor amplifiers or being degraded through the shedding of its extracellular domain or through intracellular ubiquitylation. Controlled activation of MET signalling can be exploited in regenerative medicine, whereas MET inhibition might slow down tumour progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animal Structures / metabolism
  • Animal Structures / physiology*
  • Animals
  • Growth and Development / genetics*
  • Growth and Development / physiology
  • Humans
  • Models, Biological
  • Models, Molecular
  • Neoplasms / etiology
  • Neoplasms / genetics*
  • Proto-Oncogene Proteins c-met / chemistry
  • Proto-Oncogene Proteins c-met / genetics
  • Proto-Oncogene Proteins c-met / metabolism
  • Proto-Oncogene Proteins c-met / physiology*
  • Regeneration / genetics*
  • Regeneration / physiology
  • Signal Transduction / genetics
  • Signal Transduction / physiology

Substances

  • Proto-Oncogene Proteins c-met