The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study

Clin Interv Aging. 2010 Nov 2;5:313-6. doi: 10.2147/CIA.S13432.


Objective: To evaluate for the first time the efficacy of safe-sourced phosphatidylserine-containing omega-3 long chain polyunsaturated fatty acid (PS-omega-3) in improving memory abilities.

Methods: PS-omega-3 was administered daily for 6 weeks to eight elderly volunteers with subjective memory complaints. The Cognitive Drug Research test battery was used to assess the effect on their cognitive abilities.

Results: PS-omega-3 supplementation resulted in 42% increase in the ability to recall words in the delayed condition.

Conclusion: PS-omega-3 may have a favorable effect on memory in subjects with subjective memory complaints. PS-omega-3 may serve as a safe alternative to phosphatidylserine extracted from bovine cortex.

Keywords: cognitive; memory; omega-3; phosphatidylserine.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Cattle
  • Cerebral Cortex / chemistry
  • Dietary Supplements*
  • Fatty Acids, Omega-3 / administration & dosage*
  • Fatty Acids, Omega-3 / isolation & purification
  • Female
  • Humans
  • Male
  • Memory Disorders / drug therapy*
  • Mental Recall / drug effects
  • Neuropsychological Tests
  • Phosphatidylserines / administration & dosage*
  • Phosphatidylserines / isolation & purification
  • Pilot Projects
  • Treatment Outcome


  • Fatty Acids, Omega-3
  • Phosphatidylserines